It comes as nearly half the country’s population, some 2.5 million people, are in need of assistance, and many have fled to neighbouring countries.
The humanitarian crisis in the African country erupted in 2014, as a result of onset violence between armed groups.
Commissioner of humanitarian aid and crisis management Christos Stylianides said: “Our humanitarian aid will provide essential supplies such as food, water, agricultural support and healthcare.
“Aid operations in the country are often hampered for security reasons. It is vital that humanitarian workers can deliver aid safely. Aid workers are not a target.”
Since 2014, the union and its member states have mobilised more than €500m in aid to the region to help with the crisis, which is affecting neighbouring countries, with some 573,000 refugees in Cameroon, the Democratic Republic of Congo and Chad.